Rigorous description of the fundamentals of crystallography Guide to diffraction and related experiments Provides solution to the phasing problem Offers an introduction to macromolecular crystallography Guide to crystallography for materials science Includes interactive teaching on book´s web site Updated throughout to reflect the current state of the art, and for clearer pedagogy. 95 new figures introduced, to aid understanding. Reference lists updated to reflect recent advances in the field. Many sections completely rewritten, including those on powder crystallography, electron diffraction, phase determination procedures, using the dual space procedures, and H-bonding. New material introduced, including sections on charge-transfer or donor-acceptor interactions, electron density modification methods, and humidity control of macromolecular crystals.